Organismal Systems Biology
Location
The course takes place in C-161 Baltzerstrasse 4, Tuesdays, 8:15-10.
COVID certificate is needed for the course.
There is an option to join virtually via zoom (although in presence participation is strongly encouraged):
https://unibe-ch.zoom.us/j/66288665880?pwd=cEFoaHpqSEh1KzFsWnZWS3BLSFA0UT09
Selected lectures by guest speakers may be via zoom only, which will be announced here.
Reading material
The course builds on the Systems Biology book by Uri Alon, which is highly recommended.
Recommended further study material:
online courses covering related topics:
Jeff Gore: MIT open courseware
For more advanced studies of dynamical systems read Steven Strogatz' s book and lecture.
The booklet "Optima for animals" by R. McNeill Alexander provides a beautiful introduction to optimality principles in animal development and behaviour.er
21.9. Introduction to modelling gene expression by differential equations
28.9. Negative and positive feedback
5.10. Feed-forward loops
12.10. guest lecture: Maciej Dobrzynski (IZB, Principles of moleuclar signalling networks)
19.10. ZOOM only: Attila Becskei (Biozentrum Basel, Transcriptional noise and heterogeneity)
26.10. Toggle switches and oscillatory gene expression
2.11. Exponential growth and optimality
9.11. guest lecture: Claudia Bank (IEE, Fitness landscapes and predictability of evolution)
16.11. Optimality principles in growth and aging
23.11. Cell size and gene expression (change of topic)
30.11. guest lecture: Alma dal Co (Lausanne, Microbial ecosystems and cell-cell interactions)
7.12. guest lecture: Yolanda Schaerli (Lausanne, Synthetic Biology)
14.12. Recap and Q&A
21.12. guest lecture: Jean Hausser (Karolinska Insitute, Multi-objective optimality)
Schedule
Exam
EXAM WILL BE HELD REMOTELY (CHECK YOU EMAIL!!!)
Recordings
Assignments
You can find the zoom recordings of the lectures on ILIAS.
Assignments are due on Tueday 8.15am two weeks after the respective lecture.
Submit them by email to: systemsbiology2021[at]gmail.com or drop them in my post box in Baltzerstrasse 4.
Proven effort to solve 5 out of 6 assignments correctly is required to pass the course.
Every Thursday at 3.15pm before the submission deadline, there is a Q&A session with our TA Aaditya Saxena via google meet: meet.google.com/uwi-somy-ibf
Use the forum below to ask questions about the lectures or the assignments.
